Technology ID
TAB-2730
Antigen, Encoding Gene, Related Monoclonal Antibody and Hybridoma Clones for Streptococcus pneumoniae Serological Diagnostics
E-Numbers
E-157-1991-0
Lead Inventor
Russell, Harold
Co-Inventors
Sampson, Jacquelyn
O'connor, Steven
Applications
Vaccines
Therapeutics
Research Materials
Occupational Safety and Health
Diagnostics
Consumer Products
Therapeutic Areas
Infectious Disease
Immunology
Development Stages
Pre-Clinical (in vitro)
Development Status
In vitro data available
Research Products
Antibodies
Lead IC
CDC
This CDC developed invention pertains to Streptococcus pneumoniae protein "pneumococcal fimbrial protein A (PfpA)," as well as the encoding pfpA gene. S. pneumoniae linked pneumococcal disease is prevalent among the very young, the elderly and also immunocompromised individuals. This invention covers the breadth of directly PfpA-related technology that might be employed for development of diagnostic tests for S. pneumoniae and/or vaccines directed against the pathogen. In addition to the the intellectual property protected amino acid sequence and encoding plasmid, monoclonal antibodies and corresponding hybridomas are also available.
Commercial Applications
- Screening diagnostic young, elderly and immunocompromised patients for possible S. pneumoniae infection
- Pneumococcal disease vaccine development or refinement
Competitive Advantages
- Easily adapted to a high-throughput assay for mass screening purposes
- Can be formatted as an on-site, lateral-flow diagnostic; both PfpA antigen and anti-PfpA mAb are available
Licensing Contact: