Treatment of Chronic Kidney Disease with Synthetic Amphipathic Peptides

The invention is directed to treatment of chronic kidney disease by administering a synthetic, amphipathic helical peptide known as 5A-37pA, and novel derivatives thereof. Scientists at NIDDK have demonstrated that invention peptides antagonize activity of a particular scavenger receptor known as CD36. Using an in vivo model, NIDDK scientists have shown that invention peptides slowed progression of chronic kidney disease and can potentially be utilized as a therapeutic treatment.

Additionally, certain invention peptides bind selectively to CD36 with high specificity over other homologous scavenger receptors. Thus, invention peptides can be utilized as a research tool to further evaluate the complex etiology of chronic kidney disease.

5A-37pA, and derivatives thereof, are peptide mimetic of apolipoprotein A-1. These peptides have been described in NIH owned patents and/or patent applications (see, for example, U.S. Patent Nos. 7,572,771 and 8,071,746 and 8,148,323). Use of these peptides, as well as the novel peptides of this invention, for the treatment of kidney diseases is currently available for licensing.

Potential Commercial Applications: Competitive Advantages:
  • Therapeutic
  • Selective antagonist of CD36 activity
  • Specific binding to CD36 over other scavenger receptors

Development Stage:
  • Early-stage
  • In vitro data available
  • In vivo data available (animal)

Related Invention(s):


Alan Remaley (NHLBI)  ➽ more inventions...

Ana Souza (NIDDK)  ➽ more inventions...

Peter Yuen (NIDDK)  ➽ more inventions...

Robert Star (NIDDK)  ➽ more inventions...

Alexander Bocharov (CC)  ➽ more inventions...

Thomas Eggerman (NIDDK)  ➽ more inventions...

Intellectual Property:
US Pat: - issued -
PCT Application No. PCT/US2014/060304 filed on 2014-10-13

Collaboration Opportunity:

The National Institute of Diabetes and Digestive and Kidney Diseases is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize Treatment of Chronic Kidney Disease with 5A-37pA and Derivatives Thereof. For collaboration opportunities, please contact Marguerite Miller at or 301-496-9003.

Licensing Contact:
Admin. Licensing Specialist (ALS),

OTT Reference No: E-743-2013-0
Updated: Jun 2, 2014