Monoclonal Antibody Specific for DNA/RNA Hybrid Molecules
NIAID has a hybridoma available for non-exclusive licensing that produces a monoclonal antibody specific for DNA/RNA hybrids. This antibody, which has been extensively characterized by NIH researchers, is already a widely-used research tool. It is currently the only monoclonal antibody available that is specific for DNA/RNA hybrids, making it a unique reagent. It is used in immuno-fluorescence (IF) microscopy, where it can be used to detect sites of transcriptional activity and potentially sites of viral replication. It has also been used in DNA/RNA immunoprecipitation (DRIP) experiments by a variety of researchers.
Aside from its use as a research tool, this antibody has potential to be used in diagnostic kits for viral/bacterial infections, cancers, and a variety of other human diseases. DNA/RNA hybrids arise during normal cellular function, but they are typically present in cells at low levels. When DNA/RNA hybrids are found at high levels in a cell, it indicates that the cell is "abnormal". For example, the cell may be cancerous or infected with a virus. NIH researchers have also incorporated the antibody into a micro-array platform, expanding its potential for use in diagnostic devices.
This technology is available for licensing for commercial development in accordance with 35 U.S.C. 209 and 37 CFR Part 404, as well as for further development and evaluation under a research collaboration.
Potential Commercial Applications: | Competitive Advantages: | Research tool:
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Inventors:
Stephen Leppla (NIAID) ➽ more inventions...
Clinton Leysath (NIAID) ➽ more inventions...
Damilola Phillips (NIAID) ➽ more inventions...
David Garboczi (NIAID) ➽ more inventions...
Larry Lantz (NIAID) ➽ more inventions...
Intellectual Property:
Research Tool – Patent protection is not being pursued for this technology.
Publications:
Hu Z, et al. PMID 16614443
Phillips DD, et al. PMID 23784994
Collaboration Opportunity:
The National Institute of Allergy and Infectious Diseases is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize antibodies produced by the S9.6 hybridoma. For collaboration opportunities, please contact Dr. Natalie Greco, 301-761-7898; Natalie.Greco@nih.gov.
Licensing Contact:
Michael Piziali,
Email: pizialim@niaid.nih.gov
Phone: 301-496-2644
OTT Reference No: E-738-2013-0
Updated: Dec 15, 2017