Potential New Drugs for Treating or Preventing Pruritus

NIH scientists have identified new compositions that could potentially be used to treat or prevent pruritus (itchiness). The newly discovered compounds can block a newly identified itch pathway and might be effective for persistent itch caused by psoriasis, atopic dermatitis, renal failure, liver cirrhosis and chemotherapy. These compounds are different from commonly used antihistamines which induce drowsiness and sedation. These compounds have the potential to be used for human and animals.

Potential Commercial Applications: Competitive Advantages:
  • Therapeutics for preventing or treating pruritus/itching.
  • A new category of drug for pruritus treatment.
  • Various screening tests used to minimize potential side effects.

Related Invention(s):


Mark Hoon (NIDCR)  ➽ more inventions...

Hans Solinski (NIDCR)  ➽ more inventions...

James Inglese (NCATS)  ➽ more inventions...

Patricia Dranchak (NCATS)  ➽ more inventions...

Intellectual Property:
US Application No. 15/979,105
US Application No. 62/667,843
US Application No. 62/581,420
PCT Application No. PCT/US2018/058887
US Application No. 16/761,047

Mishra SK, Hoon MA. PMID 19853036

Collaboration Opportunity:

The National Institute of Dental and Craniofacial Research is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize treatment for pruritus. For collaboration opportunities, please contact David Bradley, Ph.D. at bradleyda@nidcr.nih.gov.

Licensing Contact:
Ediz Yonter, M.S., J.D.
Email: ediz.yonter@nih.gov
Phone: 301-443-5605

OTT Reference No: E-485-2013-1
Updated: Jun 7, 2018