Rabbit Antibody to Mouse Sphingosine-1-phosphate (S1P) lyase


The cleavage of sphingoid base phosphates by sphingosine-1-phosphate (S1P) lyase to produce phosphoethanolamine and a fatty aldehyde is the final degradative step in the sphingolipid metabolic pathway. Researchers at NIH injected rabbits with the C-terminal peptide of the mouse S1P lyase — 551-TTDPVTQGNQMNGSPKPR-568 — to develop an antibody that can be used in western blotting to study this pathway.

Potential Commercial Applications: Competitive Advantages:
The antibody can be used to detect and measure S1P lyase. The antibody works very well for western blotting.


Development Stage:
In vitro data available

Inventors:

Richard Proia (NIDDK)  ➽ more inventions...


Intellectual Property:
Research Tool – Patent protection is not being pursued for this technology.

Publications:
Bektas M, et al. PMID 20097939

Licensing Contact:
Mythreyi Shastri, Ph.D.
Email: shastrim@mail.nih.gov
Phone: 301-435-0613

OTT Reference No: E-465-2013-0
Updated: Aug 6, 2013