Islet Beta Cell Only M3 Muscarinic Acetylcholine Receptor Knockout Mouse


Researchers at NIH have developed islet beta cell M3 muscarinic acetylcholine receptor knockout mouse. The mice were generated by crossing floxed mouse M3 muscarinic acetylcholine receptor mice with mice in which Cre recombinase was controlled by the beta-cell specific rat insulin promoter (RIP-Cre mice).

Potential Commercial Applications: Competitive Advantages:
Study of the physiological role of beta-cell M3 muscarinic receptors in the regulation of glucose homeostasis and insulin release in vivo. Allows for study of the role of the M3 receptors in the pancreas without whole body effects confounding the results.


Development Stage:
In vivo data available (animal)

Inventors:

Jurgen Wess (NIDDK)  ➽ more inventions...


Intellectual Property:
Research Tool — Patent protection is not being pursued for this technology.

Publications:
Gautam D, et al. PMID 16753580

Licensing Contact:
Mythreyi Shastri, Ph.D.
Email: shastrim@mail.nih.gov
Phone: 301-435-0613

OTT Reference No: E-452-2013-0
Updated: Apr 18, 2017