Nucleic Acid-based Compositions and Methods for the Detection of Pathogenic Candida or Aspergillus Fungi Species

This invention pertains to the development of oligonucleotides for the rapid nucleic acid-based identification of Candida or Aspergillus fungi species in biological samples. This identification is accomplished by the targeting the internally transcribed spacer-2 (ITS2) region that are unique to various Candida species. The assay is sensitive, specific and rapid. Implementation of the technology will facilitate earlier specific diagnoses, and lead to better antifungal therapy implementation for infected patients.

Potential Commercial Applications: Competitive Advantages:
  • Directing antifungal drug therapy for improved patient outcomes
  • Detection, discrimination of Candida and Aspergillus species from biological samples
  • Addressing secondary infections of immunosuppressed individuals
  • Easily adapted for use in kits
  • High-throughput capable
  • Rapid and cost-effective

Development Stage:
In vitro data available

Related Invention(s):


Christine Morrison (CDC)  ➽ more inventions...

Errol Reiss (CDC)  ➽ more inventions...

Brian Holloway (CDC)  ➽ more inventions...

Jong Shin (CDC)  ➽ more inventions...

Intellectual Property:
US Pat: 6,235,890 issued 2001-05-22
PCT Application No. PCT/US1997/016423 filed on 1997-09-15
US Application No. 09/269,136 filed on 1999-07-12

Shin JH, et al. PMID 9854084

Licensing Contact:
Jeremiah Mitzelfelt,
Phone: 301-443-8518

OTT Reference No: E-339-2013-0
Updated: Dec 23, 2013