Self-Expanding Stent for Valve Replacement

Aortic stenosis and aortic regurgitation are the most common types of aortic valvular diseases. Such diseased aortic valves in the body are traditionally replaced with valve prosthesis by an open surgical implantation. Available for licensing and commercial development is intellectual property covering stents for use with valve prostheses. As illustrated below, one possible embodiment of the invention includes a self-expandable stent with an elastic tubular latticework having radial and longitudinal direction. The stent geometry and mechanical parameters provide more anatomically-correct placement and the flexible scaffolding of the valve (using an interconnected four-sided polygons and longitudinal rods comprising a self-expanding stent with a plurality of struts connecting a plurality of rods) allow for secure implantation with adaptable apposition of the prosthesis in the aorta.

Potential Commercial Applications: Competitive Advantages:
  • Cardiac Surgery
  • Cardiology
  • Surgery
  • Stent implantation


Keith Horvath (NHLBI)  ➽ more inventions...

Dumitru Mazilu (NHLBI)  ➽ more inventions...

Ming Li (NHLBI)  ➽ more inventions...

Intellectual Property:
US Pat: - issued -
PCT Application No. PCT/US10/032257 filed on 2010-04-23
US Application No. 13/265,315 filed on 2011-10-19

Li M, et al. Robotic system for transapical aortic valve replacement with MRI guidance. PMID 18982639
Horvath KA, et al. Real-time magnetic resonance imaging guidance for cardiovascular procedures. PMID 18395633

Collaboration Opportunity:

The National Heart, Lung, and Blood Institute, Cardiothoracic Surgery Research Program, is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize this technology. Please contact Peg Koelbe at 301-594-4095 or for more information.

Licensing Contact:
Michael Shmilovich, J.D.
Phone: 301-435-5019

OTT Reference No: E-337-2008-0
Updated: May 17, 2018