Nucleic Acid Assays for the Detection and Discrimination of Aspergillus Fungi Species within Biological Samples
This invention relates to assays for the detection and species-specific identification of Aspergillus fungi. Accurate clinical diagnosis of Aspergillus species has become increasingly important as certain species, such as A. terreus and A. fumigatus, are resistant to specific commonly employed antifungal compounds. Most contemporary fungal diagnostic methods are time-consuming and inaccurate. This invention directly addresses those inadequacies by providing a method to rapidly and accurately differentiate all medically important species of Aspergillus based on differences in the DNA sequences of the internal transcribed spacer 1 region of ribosomal DNA.
Potential Commercial Applications: | Competitive Advantages: |
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Development Stage:
In vitro data available
Related Invention(s):
E-232-2013-0
E-293-2013-0
E-332-2013-0
Inventors:
Christine Morrison (CDC) ➽ more inventions...
Hans Hinrikson (CDC) ➽ more inventions...
Intellectual Property:
U.S. Pat: 7,384,741 issued 2008-06-10
U.S. Pat: 7,871,779 issued 2011-01-18
US Application No. 10/514,861
US Application No. 12/115,493
Publications:
Hinrikson HP, et al. PMID 15872227
Licensing Contact:
Jeremiah Mitzelfelt,
Email: jeremiah.mitzelfelt@nih.gov
Phone: 301-443-8518
OTT Reference No: E-335-2013-0
Updated: May 7, 2018