Simian T-Cell Lymphotropic Virus Strain Type 3 (STLV-3) Subtype D Variant, a Highly Divergent STLV-3, for Development of Diagnostics, Therapeutics, Vaccines and Research Tools


Simian T-cell lymphotropic viruses (STLV) are nonhuman primate retroviruses closely related to the human T-lymphotropic virus (HTLV). Types I, II, and III of HTLV have been found in humans and are believed to have originated from cross-species transmission of STLV from infected nonhuman primates. The HTLV viruses are known to cause leukemia, lymphoma, and neurological disorders.

CDC researchers discovered a strain of simian T-cell lymphotropic virus type 3 known as STLV-3 subtype D variant. STLV-3 may be widespread in primates hunted in West-Central Africa, including the monkey Cercopithecus mona, which has a known geographic habitat range from Ghana to Cameroon. This increases the risk to hunters and persons in contact with primate bushmeat for infection with STLV-3-like viruses. Thus, the discovery of the highly divergent STLV-3 subtype D variant implies that a similar virus (HTLV-3) subtype D variant could be spreading undetected in humans.

Potential Commercial Applications: Competitive Advantages:
  • Diagnostic reagents for clinical and research testing for STLV-3-like viruses in humans
  • Diagnostic reagents for screening the blood supply for STLV-3 subtype D variant
  • Testing of divergent strains of STLV and HTLV for susceptibility to known or experimental antiretrovirals (ARV drugs) using in vitro assays
  • Reagents for vaccines to HTLV
  • Zoonosis monitoring and surveillance
  • Simian/human T-cell lymphotropic virus research
 
  • Allows for detection of STLV strain STLV-3 subtype D variant
  • Facilitates monitoring of viral diversity and study of zoonotic disease transmission


Related Invention(s):
E-281-2013-0


Inventors:

Donald Burke

William Switzer (CDC)  ➽ more inventions...

Walid Heneine (CDC)  ➽ more inventions...

Thomas Folks (CDC)  ➽ more inventions...

Nathan Wolfe

David Sintasath


Intellectual Property:
U.S. Pat: 8,663,968 issued 2014-03-04
US Application No. 12/600,995
US Application No. 14/013,947
International patents granted in Australia, Canada, and Europe.

Publications:
Liégeois, F. et al. PMID 17976676
Sintasath, DM et al. PMID 19193260

Collaboration Opportunity:

The CDC Technology Transfer Office (TTO) is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize: Simian T-Cell Lymphotropic Virus Strain Type 3 (STLV-3) Subtype D Variant for Development of Diagnostics, Therapeutics, Vaccines and Research Tools For collaboration opportunities, please contact CDC TTO at tto@cdc.gov or 1-404-639-1330.


Licensing Contact:
Jeremiah Mitzelfelt,
Email: jeremiah.mitzelfelt@nih.gov
Phone: 301-443-8518

OTT Reference No: E-303-2013-2
Updated: Oct 17, 2018