Multiple Antigenic Peptide Assays for Detection of HIV and SIV Type Retroviruses

CDC scientists have developed multiple antigenic peptide immunoassays for the detection of human immunodeficiency virus (HIV) and/or simian immunodeficiency virus (SIV). HIV can be subdivided into two major types, HIV-1 and HIV-2, both of which are believed to have originated as result of zoonotic transmission. Humans are increasingly exposed to many different SIVs by wild primates. For example, human exposure to SIVs frequently occurs as a consequence of the bush meat hunting and butchering trade in Africa. Human exposure to SIVs may lead, or may have already led, to transmission of SIVs with potential for new virus induced immunodeficiency epidemics. Unfortunately, new cases of zoonotic virus transmission may go undetected because of the lack of SIV-specific tests. Thus, there is the potential to compromise the safety of the blood donor supply system and seed a new HIV-like epidemic. This invention addresses these problems by providing a way to test all primates for the many divergent lentivirus strains to identify primary infections and prevent secondary transmission.

Potential Commercial Applications: Competitive Advantages:
  • Detection and differentiation of HIV-1, HIV-2 and SIVs
  • HIV/SIV surveillance
  • SIV/HIV/AIDS research
  • Sero-monitoring of potential zoonotic transmissions
  • Blood-donation supply assurance tool
  • Fills an unmet need for SIV-specific tests
  • Sensitive and specific
  • Easily adapted to kit/array format
  • Research indicates greater sensitivity than standard HIV enzyme immunoassays (EIAs) for detecting SIV infections

Development Stage:
In vitro data available


Marcia Kalish (CDC)  ➽ more inventions...

Clement Ndongmo (CDC)  ➽ more inventions...

Chou-Pong Pau (CDC)  ➽ more inventions...

William Switzer (CDC)  ➽ more inventions...

Thomas Folks (CDC)  ➽ more inventions...

Intellectual Property:
US Pat: 8,524,461 issued 2013-09-03
PCT Application No. PCT/US2004/011022 filed on 2004-04-08
US Application No. 60/462,071 filed on 2003-04-11
US Application No. 12/717,276 filed on 2010-03-04
Various international patent applications pending or issued

Ndongmo CB, et al. PMID 15528710
Kalish ML, et al. PMID 16485481

Licensing Contact:
Jeremiah Mitzelfelt,
Phone: 301-443-8518

OTT Reference No: E-294-2013-0
Updated: Feb 7, 2014