Personalized Cancer Evaluation (PERCEVAL) Method and Software
Cancer represents the leading cause of morbidity and mortality worldwide, with approximately 14 million new cases and 8.2 million cancer related deaths in 2012. This number is predicted to rise by approximately 70% over the next two decades according to the World Health Organization. Prognosis depends heavily on both early detection and frequent monitoring of the patient's response to treatment. Cancerous tumors shed nucleic acids into blood, which can be detected by ultra-deep sequencing of mitochondrial DNA (mtDNA). This method has the potential to provide early detection in asymptomatic individuals or those with vague, undefined symptoms. Currently, researchers are identifying specific changes in the whole human genome that occur in tumors of patients. These targeted sequences are then compared to other individuals.
Unfortunately, cancer mutations are often unique to a patient or are uncommon across patients with similar cancers. CDC researchers developed PERCEVAL, a software that is capable of detecting cancer in asymptomatic individuals based on mitochondrial DNA (mtDNA). In addition to early detection, PERCEVAL has the potential to determine the severity of the cancer and monitor whether a given therapy is working for an individual patient.
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Inventors:
David Campo (CDC) ➽ more inventions...
Intellectual Property:
US Application No. 62/459,406
PCT Application No. PCT/US2018/017962
US Application No. 16/485,714
Collaboration Opportunity:
The CDC Technology Transfer Office (TTO) is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize: Personalized Cancer Evaluation (PERCEVAL) Software and Method. For collaboration opportunities, please contact CDC TTO at tto@cdc.gov or 1-404-639-1330.
Licensing Contact:
Jeremiah Mitzelfelt,
Email: jeremiah.mitzelfelt@nih.gov
Phone: 301-443-8518
OTT Reference No: E-289-2016-0
Updated: Feb 14, 2018