Novel Human Rotavirus Vaccine CDC-6 Strain for Impacted Subgroup, the Lewis Negative Population

Rotaviral infection is the most common gastrointestinal illness of children in the world, affecting both developed and developing economies. There is no specific drug treatment for rotavirus infection. Vaccination and good hygiene are key to prevention.

Approximately 5-10% of the world's population are Lewis histoblood group antigen negative, that percentage is as high as 30% in some African countries. Despite vaccination, the Lewis negative population show a disproportionate prevalence and recurrence of rotavirus infection. However, initial studies have shown that infection with a rotavirus G9P[6] strain may provide improved protection within this group. Inventors have isolated a human rotavirus G9P[6] strain, designated CDC-6, that grows to a high titer with a stable outer structure, making it an ideal vaccine candidate strain. The CDC-6 strain possesses favorable virological and molecular features and may serve as a promising candidate for a new live oral or an inactivated rotavirus vaccine. CDC seeks partners to jointly develop this technology in pre-clinical and clinical testing.

Potential Commercial Applications:		Competitive Advantages:
Novel rotavirus vaccines Neonatal/childhood vaccination initiatives Large scale antigen production Use in diagnostics of rotavirus disease Rotavirus surveillance programs, important for both developing and developed nations New vaccine candidate option for animals Research tool		Broader population coverage (both the Lewis-positive and negative population) Isolated strains are representative of those involved in community-acquired infection Suitable for the development of improved, broadly effective rotavirus vaccines; no current vaccine has the P[6] antigen strain Potential for a new inactivated injection and/or live oral vaccine format May be administered alone or in combination with other vaccines First human G9P[6] genotype that can grow to high titer in Vero cells Shown to maintain the integrity of triple layered particles during upstream and downstream process

Related Invention(s):
E-150-2013-0
E-153-2013-0
E-191-2013-0


Inventors:

Baoming Jiang (CDC)  ➽ more inventions...

Yuhuan Wang (CDC)  ➽ more inventions...


Intellectual Property:
US Pat: 10,548,970 issued 2020-02-04
PCT Application No. PCT/US2016/054211 filed on 2016-09-28
US Application No. 15/765,716 filed on 2018-04-03
US Application No. 16/717,946 filed on 2019-12-17

Collaboration Opportunity:
The CDC Technology Transfer Office (TTO) is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize: Novel Human Rotavirus Vaccine CDC-6 Strain for Impacted Subgroup, the Lewis Negative Population. For collaboration opportunities, please contact CDC TTO at tto@cdc.gov.


Licensing Contact:
Karen Surabian, J.D., M.B.A.
Email: karen.surabian@nih.gov
Phone: 301-594-9719

OTT Reference No: E-285-2015-0
Updated: Dec 26, 2019