Molecular Detection and Viral-Load Quantification for HIV-1 Groups M, N and O, and Simian Immunodeficiency Virus-cpz (SIVcpz)

This invention provides materials, methods, and assays for detecting HIV-1 groups M and O and optionally HIV-1 group N and simian immunodeficiency virus-cpz (SIV-cpz). Specific nucleic acid primers for hybridization, amplification, and detection of HIV-1 are also provided for. The nucleic acid amplification assays can detect small concentrations of HIV-1 and are also useful for quantitative examinations of viral load concentrations within biological samples.

Potential Commercial Applications: Competitive Advantages:
  • Blood and plasma donation screening
  • Diagnostic detection of HIV-1
  • Public health programs
  • Monitoring HIV treatment and disease inhibition/progression
  • Broad-use, generic viral detection for groups M, N and O HIV-1, and also SIVcpz
  • Requires minute quantities of virus for use, making this assay ideal for confirmation of early-stage infection
  • Sensitive and highly specific
  • Easily formulated for kits
  • Established efficacy in patient samples

Development Stage:
  • In vitro data available
  • In situ data available (on-site)


Renu Lal (CDC)  ➽ more inventions...

Danuta Pieniazek (CDC)  ➽ more inventions...

Intellectual Property:
US Pat: 8,575,324 issued 2013-11-05
US Application No. 09/890,551 filed on 2001-08-01
PCT Application No. PCT/US2000/002498 filed on 2000-02-01
US Application No. 60/118,357 filed on 1999-02-03
US Application No. 11/645,988 filed on 2006-12-27

Yang C, et al. PMID 10823786

Licensing Contact:
Jeremiah Mitzelfelt,
Phone: 301-443-8518

OTT Reference No: E-271-2013-0
Updated: Jan 28, 2014