Image Analysis Software for Quantitative Evaluation of Striation Patterns and their Defects in Skeletal Muscles

Available for licensing is software written in MatLab for evaluating striation patters in images of skeletal muscle fibers for better sensitivity in the quantitation of skeletal muscle disorders. Skeletal muscles have a regular, periodic organization (the periodicity of the sarcomeres), which is not only structural but also functional. Muscle pathologies create disorder in the normally periodic myofibrils. Objective grading of muscle morphology is necessary to assess muscle health, compare biopsies, and evaluate treatments and the evolution of disease.

Potential Commercial Applications: Competitive Advantages:
Drug development for muscular disorders. Automated analysis of sarcomere dysplasia for objective grading of muscle morphology.

Development Stage:


Wenhua Liu (NIAMS)  ➽ more inventions...

Evelyn Ralston (NIAMS)  ➽ more inventions...

Intellectual Property:
Software Research Tool — Patent protection is not being pursued for this technology.

Plotnikov SV, et al. PMID19021346
Friedrich O, et al. PMID 20159157
Llewellyn ME, et al. PMID 18600262

Collaboration Opportunity:

The Light Imaging Section of NIAMS, NIH, is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize software for image analysis of cells and tissues and skeletal muscle. For collaboration opportunities, please contact Wenhua Liu at or 301-451-4815.

Licensing Contact:
Michael Shmilovich, J.D.
Phone: 301-435-5019

OTT Reference No: E-264-2012-0
Updated: Sep 10, 2012