A VSV-EBOV-Based Vaccine Against COVID-19

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of for coronavirus disease 2019 (COVID-19). COVID-19 is characterized by fever, cough, difficulty breathing, loss of taste and smell, nausea, and sore throat. As of the fourth quarter 2020, COVID-19 is responsible for over 1.17 million deaths worldwide. As the pandemic continues to surge, the importance of a safe, affordable, and efficacious vaccine is of urgent importance. The present technology utilizes the well characterized vesicular stomatitis virus (VSV) encoding the Ebola virus (VSV-EBOV) to express additionally a codon-optimized SARS-CoV-2 spike protein. A single intranasal or intramuscular administration of the vaccine showed protective efficacy against COVID-19 in hamsters after 4 weeks. A single intramuscular injection showed protective efficacy against COVID-19 pneumonia in rhesus macaques within 10 days. The vaccine is inexpensive to replicate, elicits a high antigen-specific antibody titer within the host, and provides protective efficacy after a single dose.

Potential Commercial Applications: Competitive Advantages:
  • Single dose vaccine against COVID-19
  • Utilizes the established and well characterized VSV-EBOV vector
  • Expresses high antigen titers within host cells
  • Single dose protective efficacy against COVID-19
  • Inexpensive and replicable


Andrea Marzi (NIAID)  ➽ more inventions...

Wakako Asada (NIAID)  ➽ more inventions...

Intellectual Property:
Research Material - Patent protection is not being pursued for this technology

Collaboration Opportunity:

This technology is available for licensing, as a biological material, for commercial development in accordance with 35 U.S.C. 209 and 37 CFR part 404. To license this technology, please contact Jeffrey Thruston at 301-594-5179 or Jeffrey.Thruston@nih.gov, and reference E-258-2020-0.

Licensing Contact:
Jeffrey Thruston,
Email: jeffrey.thruston@nih.gov
Phone: 301-594-5179

OTT Reference No: E-258-2020-0
Updated: Feb 5, 2021