Polyclonal Antibodies to Thiazide-Sensitive Sodium-Chloride Cotransporter (NCC)

Antibodies to thiazide-sensitive sodium-chloride cotransporter (NCC), useful for immunoblotting and immunocytochemistry, are available to resell for research purposes. NCC is found on the apical membrane of the distal convoluted tubule, where it is the principal mediator of Na+ and CI- reabsorption in this segment of the nephron. NCC is the target of thiazide diuretics used in the treatment of hypertension. The inventors have developed rabbit polyclonal antibodies directed against a peptide sequence in the C-terminal region of NCC.

Potential Commercial Applications: Competitive Advantages:
Western blotting and immunohistochemistry 


Mark Knepper (NHLBI)  ➽ more inventions...

Intellectual Property:
Research Tool -- patent protection is not being pursued for this technology

HL Biner, MP Arpin-Bott, J Loffing, X Wang, M Knepper, SC Hebert, B Kaissling. Human cortical distal nephron: distribution of electrolyte and water transport pathways. J Am Soc Nephrol. 2002 Apr;13(4):836-847. PubMed abs

Licensing Contact:
Michael Shmilovich, J.D.
Email: shmilovm@mail.nih.gov
Phone: 301-435-5019

OTT Reference No: E-254-2008-0
Updated: May 5, 2009