Broadly Neutralizing Human Anti-HIV Monoclonal Antibody 10E8 and Related Antibodies Capable of Neutralizing Most HIV-1 Strains
The uses for human anti-HIV monoclonal antibody 10E8 and its variants include passive immunization, therapeutic vaccination, and the development of vaccine immunogens. 10E8 is one of the most potent HIV-neutralizing antibodies isolated and it neutralizes up to 98% of diverse HIV-1 strains. 10E8 is specific to the membrane-proximal external region (MPER) of the HIV envelope protein gp41 and 10E8 is orthogonal to other anti-HIV antibodies. In combination with other antibodies 10E8 may provide an antibody response that neutralizes nearly all strains of HIV-1. Additionally, 10E8 effectively induces antibody-dependent cellular cytotoxicity (ADCC) indicating its potential use for therapeutic vaccine strategies. Further, 10E8 is a tool for immunogen design and validation of immunogen structure.
NIAID is currently developing certain embodiments of 10E8 for clinical use. Therefore, for some fields of use, NIH will evaluate a license applicant's capabilities and experience in advancing similar technologies through the regulatory process. This technology is not eligible for the NIH's start-up license program.
Potential Commercial Applications: | Competitive Advantages: |
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Development Stage:
- In vitro data available
- In vivo data available (animal)
Inventors:
John Mascola (NIAID) ➽ more inventions...
Mark Connors (NIAID) ➽ more inventions...
Leo Laub (NIAID) ➽ more inventions...
Jinghe Huang (NIAID) ➽ more inventions...
Peter Kwong (NIAID) ➽ more inventions...
Gilad Ofek (NIAID) ➽ more inventions...
Jiang Zhu (NIAID) ➽ more inventions...
Gary Nabel (NIAID) ➽ more inventions...
Rebecca Rudicell (NIAID) ➽ more inventions...
Ivelin Georgiev (NIAID) ➽ more inventions...
Yongping Yang (NIAID) ➽ more inventions...
Intellectual Property:
U.S. Pat: 9,783,595 issued 2017-10-10
U.S. Pat: 9,475,862 issued 2016-10-25
U.S. Pat: 10,047,148 issued 2018-08-14
US Application No. 61/698,480
PCT Application No. PCT/US2012/063958
US Application No. 14/356,557
US Application No. 15/699,902
Publications:
Huang J, et al. PMID 23151583
Collaboration Opportunity:
The National Institute of Allergy and Infectious Diseases is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize 10E8-related vaccines or immunotherapies. For collaboration opportunities, please contact Bill Ronnenberg at +1 240-627-3726 or wronnenberg@niaid.nih.gov.
Licensing Contact:
Christopher Kornak, J.D.
Email: chris.kornak@nih.gov
Phone: 240-627-3705
OTT Reference No: E-253-2011-0
Updated: Jun 18, 2014