Magnetic Resonance Magnification Imaging

With conventional MRI, it is inherently time-consuming to generate high dimensional images with high spatial resolution. This invention, inspired by optical magnification, uses a fundamentally different approach to MRI image formation. It uses specially designed radiofrequency pulses to interact with the magnetic field gradient, wherein the region of interest is filled with more pixels resulting in increased spatial resolution and reduced overall scan times. Currently, 3-fold magnification has been achieved in vivo. This invention allows the magnification of predefined regions of interest and improved diagnostic images for the same scan time.

Potential Commercial Applications: Competitive Advantages:
  • Diagnostic imaging
  • Environmental Sampling/Testing
  • Quality Control/Quality Assurance
  • Magnified image with increased image resolution at regions of interest
  • A 3-fold increase in spatial resolution at regions of interest in vivo in comparison to traditional MRI scans
  • Reduced scan time
  • Patient friendly - with reduced scan time, there is less patient discomfort especially for those who experience claustrophobia

Development Stage:
  • Early-stage
  • In vivo data available (animal)


Jun Shen (NIMH)  ➽ more inventions...

Intellectual Property:
PCT Pat: - issued -
US Application No. 62/059,520 filed on 2014-10-03
US Application No. 15/516,339 filed on 2017-03-31

Collaboration Opportunity:

The National Institute of Mental Health is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize Magnetic Resonance Magnification Imaging. For collaboration opportunities, please contact Jun Shen at or 301-451-3408.

Licensing Contact:
Jennifer Wong, M.S.
Phone: 301-480-4821

OTT Reference No: E-252-2014-0
Updated: Jan 12, 2017