Thymosin alpha 1 Promotes Tissue Repair, Angiogenesis and Cell Migration


These applications describe the use of the compound thymosin alpha 1 as an agent for promoting wound healing. Thymosin alpha 1 is a small, 28 mer, peptide which can be made by chemical synthesis or recombinantly. Studies using a punch model for wounds in rats have shown that providing thymosin alpha1 either intraperitoneally or topically accelerates wound healing. In addition, thymosin alpha 1 has been shown to promote endothelial and keratinoctye cell migration in vivo and to promote angiogenesis in vivo.

Inventors:

Katherine Malinda (NIDCR)  ➽ more inventions...

Hynda Kleinman (NIDCR)  ➽ more inventions...

Allan Goldstein

Intellectual Property:
US Application No. 60/065,032

Publications:
This work has been published in J. Immunol. 160(2): 1001-6 (Jan 15, 1998).

Licensing Contact:
Vladimir Knezevic, M.D.
Email: vlado.knezevic@nih.gov
Phone: 301.443.5560

OTT Reference No: E-250-1997-0
Updated: May 16, 2016