T24 Antigen for Diagnosing or Treating Taenia solium Cysticercosis


In order to develop a simple detection assay for field use, CDC researchers cloned and sequenced the Taenia solium T24 diagnostic protein. The T24 sequences can be used to detect and diagnose T. solium infection or can be formulated into a pharmaceutical composition. T. solium is a species of tapeworm. Intestinal infection with T. solium is referred to as taeniasis. Many taeniasis infections are asymptomatic but may be characterized by insomnia, anorexia, abdominal pain and weight loss. Cysticercosis infection, which can be fatal, may develop if T. solium larvae migrate out of the intestine and form cysticerci in various body tissues. This technology may be used to develop a diagnostic, vaccine, or therapeutic for infection related to T. solium.

Potential Commercial Applications: Competitive Advantages:
  • Vaccine or therapeutic for taeniasis or cysticercosis resulting from T. solium infection
  • Diagnosis of T. solium infection
  • Zoonotic disease research and surveillance
  • Public health monitoring programs
  • Livestock health and food-source monitoring
 
  • Rapid, accurate, sensitive, and safe compared to current radiologic and biopsy diagnostic methods
  • Easy-to-use diagnostic kit that doesn't require abnormal temperatures or specialized equipment
  • Can be developed for serologic and/or nucleic acid diagnostics
  • Cost-effective; useful for developing countries


Development Stage:
  • Early-stage
  • In vitro data available


Related Invention(s):
E-247-2013-0


Inventors:

Kathy Hancock (CDC)  ➽ more inventions...

Fatima Williams (CDC)  ➽ more inventions...

Melinda Yushak (CDC)  ➽ more inventions...

Sowmya Pattabhi (CDC)  ➽ more inventions...

Victor Tsang (CDC)  ➽ more inventions...


Intellectual Property:
U.S. Pat: 7,547,762 issued 2009-06-16
U.S. Pat: 7,972,606 issued 2011-07-05
US Application No. 10/557,265
US Application No. 12/431,928

Licensing Contact:
Jeremiah Mitzelfelt,
Email: jeremiah.mitzelfelt@nih.gov
Phone: 301-443-8518

OTT Reference No: E-237-2013-0
Updated: Oct 23, 2013