Spatial and Temporal Control of Gene Expression Using a Heat Shock Protein Promoter in Combination with Local Heat


In many instances, it is desirable to express exogenous genes only in certain tissues, and/or at will at certain times, and/or only to a certain degree. However, current gene transfer and exogenous gene expression protocols do not provide adequate means of simultaneously controlling which cells in a heterogeneous population are transformed and when, where, and to what degree the transferred genes are expressed. The invention provides methods for using local heat to control gene expression. The heat shock protein (hsp) gene promoter is recombined with a selected therapeutic gene and expressed in selected cells. Local controlled heating is used to activate the hsp promoter, for example by using focused ultrasound controlled by MRI.

Inventors:

Chrit Moonen (NIBIB)  ➽ more inventions...


Intellectual Property:
US Pat: 7,186,698 issued 2007-03-06
EP Application No. 10/096,549 filed on 2002-03-11
US Application No. 60/024,213 filed on 1996-08-15
US Application No. PCT/US97/15270 filed on 1997-08-14
PCT Application No. 09/242,244 filed on 2000-02-29

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OTT Reference No: E-235-1995-0
Updated: May 1, 2005