WNT1-Induced Secreted Protein-1 Knockout Mouse Model

WNT1-induced secreted protein-1 (WISP1) is expressed at high levels in osteoblasts and their precursors. WIPS1 plays an important role in various aspects of bone formation. Scientists at the NIH generated Wisp1-deficient (Wisp1^-/-) mice. Deletion of Wisp1 resulted in a decrease in bone mineral density, total bone volume, bone thickness, and biomechanical strength. Wisp1 knockout mouse model can be used to study the molecular mechanisms of bone turnover and patho/physiology of tissues that express WISP1.

Potential Commercial Applications:		Competitive Advantages:
To study the molecular mechanisms of bone formation and osteodifferentiation. To study the patho/physiology of tissues that express WISP1, including cartilage during osteoarthritis, healing skin, and other soft tissues including lung, pancreas, and heart.

Development Stage:
In vivo data available (animal)

Inventors:

Marian Young (NIDCR)  ➽ more inventions...

Mitsuaki Ono (NIDCR)  ➽ more inventions...

Azusa Maeda (NIDCR)  ➽ more inventions...


Intellectual Property:
Research Tool - Patent protection is not being pursued for this technology.

Publications:
Maeda A, et al. PMID 25864198

Collaboration Opportunity:
The National Institute of Dental and Craniofacial Research is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize WNT1-Induced Secreted Protein-1 Knockout Mouse Model. For collaboration opportunities, please contact David Bradley, Ph.D. at bradleyda@nidcr.nih.gov.


Licensing Contact:
Vladimir Knezevic, M.D.
Email: vlado.knezevic@nih.gov
Phone: 301.443.5560

OTT Reference No: E-234-2015-0
Updated: Aug 6, 2015