Capillary Viscometer for Measuring Viscosity of Macromolecular Solutions of Biological Relevance

A capillary-based device and system for measuring the rheological properties of solutions of synthetic and biological polymers. The device automatically serially dilutes and varies the flow rate of a sample, permitting measurement of solution viscosity across wide ranges of concentration and shear rate without changing samples. The device can rapidly and accurately assay solute stability, solute-solvent and solute-solute interactions in solutions of proteins and other macromolecules of biotechnological and pharmaceutical interest, as well as solution injectability.

Potential Commercial Applications: Competitive Advantages:
  • Rapid characterization of composition-dependent rheological properties of candidate biopharmaceuticals and industrial polymers.
  • Automatic variation of solute concentration
  • Automatic variation of shear rate
  • Direct measurement of solution injectability

Development Stage:
  • Prototype
  • In vitro data available


Allen Minton (NIDDK)  ➽ more inventions...

Asaf Grupi (NIDDK)  ➽ more inventions...

Intellectual Property:
US Pat: - issued -
US Application No. 14/419,914 filed on 2015-02-05
PCT Application No. PCT/US2013/055786 filed on 2013-08-20


Grupi A, Minton AP. Capillary viscometer for fully automated measurement of the concentration and shear dependence of the viscosity of macromolecular solutions. Anal Chem. 2012 Dec 18;84(24):10732-6.

PMID: 23130673

Grupi A, Minton AP. Concentration-dependent viscosity of binary and ternary mixtures of nonassociating proteins: measurement and analysis. J Phys Chem B. 2013 Nov 7;117(44):13861-5.

PMID: 24131130

Collaboration Opportunity:

The National Institute of Diabetes and Digestive and Kidney Diseases is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize automated capillary viscometer. For collaboration opportunities, please contact Allen P. Minton at or Asaf Grupi at

Licensing Contact:
Vladimir Knezevic, M.D.
Phone: 301.443.5560

OTT Reference No: E-231-2012-0
Updated: Sep 6, 2016