Functional Promoter For CCR5


Embodied in this invention is the identification of the functional promoter sequence for CCR5. CCR5 is a known chemokine receptor which functions as a cofactor for HIV binding and is found on the cell surface of macrophages and CD4+ T cells. Blocking or suppressing the expression of CCR5 may therefore serve to inhibit HIV infection. It is postulated that this could be accomplished by inhibiting the CCR5 promoter or by administering an oligonucleotide analog of the promoter, thereby treating or preventing HIV infection. Polynucleotide sequences are provided by the invention. Therapeutic approaches and pharmaceutical compositions are claimed, as are research uses.

Inventors:

Florence Guignard (NIAID)  ➽ more inventions...

Philip Murphy (NIAID)  ➽ more inventions...

Christophe Combadiere (NIAID)  ➽ more inventions...

Harry Tiffany (NIAID)  ➽ more inventions...


Intellectual Property:
U.S. Pat: 6,383,746 issued 2002-05-07
US Application No. 60/065,934

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OTT Reference No: E-222-1997-0
Updated: May 17, 2016