Mouse Lacking the Chemokine Receptor CX3CR1


This mouse has been generated by targeted gene disruption. The mouse provides a model to investigate the function of the chemokine receptor CX3CR1, which is a proinflammatory receptor for the leukocyte chemoattractant CX3CL1 (aka fractalkine). As an example, the mouse is in use in the study of atherosclerosis. Further, the mouse may serve as a model study the role of the immune system during infection with pathogens as well as other immunologically mediated diseases and responses to tumors.

Inventors:

Jiliang Gao (NIAID)  ➽ more inventions...

Philip Murphy (NIAID)  ➽ more inventions...


Intellectual Property:
Research Tool -- patent protection is not being pursued for this technology

Publications:
C Combadière et al. Decreased atheroscelerotic lesion formation in CX3R1/apolipoprotein E double knockout mice. PubMed: 12600915

Licensing Contact:
Charles Rainwater,
Email: crainwater@niaid.nih.gov
Phone: 301-496-2644

OTT Reference No: E-216-2003-0
Updated: Mar 1, 2010