IL-21 Critically Regulates Immunoglobulin Production


The invention includes a mouse in which the IL-21 receptor gene is disrupted by homologous recombination, the disruption being sufficient to prevent expression of the IL-21 receptor and thus to inhibit the action of IL-21. The invention also includes a mouse in which both the IL-21 receptor gene and the IL-4 gene are simultaneously disrupted in fashions being sufficient to inhibit the action of IL-21 and the production of IL-4. In a homozygous state, these mutations produce a mouse that has diminished B cell function.

This invention also relates to the use of agents that inhibit the interaction of IL-21 with the IL-21 receptor to modulate an immune response. This invention may be used to alter B cell activity, to treat a subject with Job's disorder, to treat an allergic reaction in a subject, or prevent an allergic reaction in a subject,

Inventors:

Warren Leonard (NHLBI)  ➽ more inventions...

Katsutoshi Ozaki (NHLBI)  ➽ more inventions...

Rosanne Spolski (NHLBI)  ➽ more inventions...


Intellectual Property:
US Pat: 7,332,645 issued 2008-02-19
PCT Application No. 11/027,868 filed on 2004-12-30

Licensing Contact:
Vincent Kolesnitchenko, Ph.D.
Email: vk5q@nih.gov
Phone: 301-594-4115

OTT Reference No: E-211-2002-0
Updated: May 1, 2004