Methods of Treating Colitis Using STAT-4 Antisense Oligonucleotide


This invention described in this patent application relates to compositions and methods which can be used to treat diseases such as Crohn's disease, a form of inflammatory bowel disease. This disease has been linked to the interferon gamma (IFNgamma) response induced by interleukin 12 (IL-12) production. Recent work has shown that IFNgamma production is also a product of the activation of the signal transduction molecule Signal Transducer and Activator of Transcription-4 (STAT-4). Therefore, regulation of IFNgamma production rather than IL-12 production may be a more effective means of treatment.

The methods and compositions described in this patent application are antisense oligonucleotides derived from STAT-4 which inhibit the STAT-4 pathway. The antisense compositions have been studied in animal models, IL-10 knockout mice and mice having TNBS colitis. In these studies local administration of the antisense oligonucleotides rapidly reversed intestinal inflammation.

Inventors:

Warren Strober (NIAID)  ➽ more inventions...

Markus Neurath (NIAID)  ➽ more inventions...

Atsushi Kitani ()  ➽ more inventions...


Intellectual Property:
U.S. Pat: 6,479,465 issued 2002-11-12
US Application No. 09/812,028
US Application No. 09/535,025

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OTT Reference No: E-200-1997-0
Updated: Jul 1, 1999