Amino Acid Substitutions Mutants of Anthrax Protective Antigen, Lethal Factor, and Edema Factor
Anthrax toxin proteins available for licensing. Bacillus anthracis hosts containing plasmids expressing the following proteins are available. (Host strains are generally BH480, or sometimes BH460. Modest amounts of purified proteins (10-50 mg) could also be provided):
- PA. Protective antigen, wild type
- PA-3M (PA D683A, L685E, Y688K)
- PA-3M Cys
- PA-U7
- PA F427A
- PA K563C
- PA L687A
- PA-U7 K562C
- PA D512K
- PA GN
- PA-3M SoSi-H6
- FP59-AGG
- EF-A K313R
- LFn-linker-Cys
- LF E687A
- LFnBLA
- LFnFLA
Potential Commercial Applications: | Competitive Advantages: |
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Inventors:
Stephen Leppla (NIAID) ➽ more inventions...
Intellectual Property:
Research Material – Patent protection is not being pursued for this technology. (IC Reference No. 2014-019)
Licensing Contact:
Michael Piziali,
Email: pizialim@niaid.nih.gov
Phone: 301-496-2644
OTT Reference No: E-196-2014-0
Updated: Jun 7, 2018