Amino Acid Substitutions Mutants of Anthrax Protective Antigen, Lethal Factor, and Edema Factor

Anthrax toxin proteins available for licensing. Bacillus anthracis hosts containing plasmids expressing the following proteins are available. (Host strains are generally BH480, or sometimes BH460. Modest amounts of purified proteins (10-50 mg) could also be provided):

1. PA. Protective antigen, wild type
2. PA-3M (PA D683A, L685E, Y688K)
3. PA-3M Cys
4. PA-U7
5. PA F427A
6. PA K563C
7. PA L687A
8. PA-U7 K562C
9. PA D512K
10. PA GN
11. PA-3M SoSi-H6
12. FP59-AGG
13. EF-A K313R
14. LFn-linker-Cys
15. LF E687A
16. LFnBLA
17. LFnFLA

Potential Commercial Applications:		Competitive Advantages:
A research material that can be used in the development of assays, validation of products or in quality control.		Speed up product development with NIH developed material that has already been tested and validated.

Inventors:

Stephen Leppla (NIAID)  ➽ more inventions...


Intellectual Property:
Research Material – Patent protection is not being pursued for this technology. (IC Reference No. 2014-019)

Licensing Contact:
Michael Piziali,
Email: pizialim@niaid.nih.gov
Phone: 301-496-2644

OTT Reference No: E-196-2014-0
Updated: Jun 7, 2018