Nucleotide, Deduced Amino Acid Sequence, Isolation And Purification Of Heat-Shock Chlamydial Proteins


This invention concerns the discovery of a novel gene that encodes the HSP60 protein from Chlamydia trachomatis, referred to as HypB in the application. This immunodominant protein is a major target for Chlamydia trachomatis vaccine development and diagnostics. This gene and protein, or fragments thereof, are useful in the development of both recombinant protein and DNA based vaccines. The recombinant protein or DNA sequence also have potential for the development of diagnostic tests for C. trachomatis. The three patent properties claim different aspects of the invention. U.S. Patent No. 5,071,962 claims monoclonal antibodies reactive against C. trachomatis HSP60 protein. U.S. Patent Application No. 07/841,323 claims the HSP60 protein and its use as a vaccine. U.S. Patent 6,423,835 claims DNA sequences, and protein fragments thereof, encoding HSP60. This DNA sequence would be useful in a DNA vaccine, alone or with the MOMP DNA sequences claimed in U.S. Patent 5,869,608 (HHS Reference No. E-003-1989/0). No foreign patent rights exist.

Inventors:

Richard Morrison (NIAID)  ➽ more inventions...

Harlan Caldwell (NIAID)  ➽ more inventions...


Intellectual Property:
US Pat: 6,423,835 issued 2002-07-23
US Pat: 5,071,962 issued 1991-12-10
US Application No. 07/531,317 filed on 1990-05-31
US Application No. 07/679,302 filed on 1991-04-02

Licensing Contact:
Jeffrey Thruston,
Email: jeffrey.thruston@nih.gov
Phone: 301-594-5179

OTT Reference No: E-196-1989-0
Updated: Feb 28, 2011