Development of Immune System Tolerance for the Treatment of Autoimmune Disease

The present invention provides a therapeutic method for the treatment of autoimmune or autoinflammatory diseases by first breaking down the dysregulated immune system and then reprogramming the immune system to restore tolerance to the patient's self-antigens by induction of antigen specific regulatory T cells. The inventors have shown that only with the combination of apoptosis, phagocytes, and antigen can antigen-specific regulatory T cells (Treg) cells be optimally generated to develop long-term immune tolerance. This strategy for developing immune tolerance can be applied to the treatment of autoimmune diseases.

Potential Commercial Applications: Competitive Advantages:
  • Treatment of autoimmune disease.
  • This technology represents a novel means of treating autoimmune disease.

Development Stage:
  • Early-stage
  • In vivo data available (animal)


Wanjun Chen (NIDCR)  ➽ more inventions...

Intellectual Property:
US Application No. 14/904,054
US Application No. 61/844,564
PCT Application No. PCT/US14/046065
US Application No. 16/773,982
US Application No. 17/167,737

Licensing Contact:
Ediz Yonter, M.S., J.D.
Phone: 301-443-7494

OTT Reference No: E-186-2009-0
Updated: Feb 11, 2016