Silica-Coated Nanodiamonds for Imaging and Delivery of Therapeutic Agents
The NCI Radiation Oncology Branch and the NHLBI Laboratory of Single Molecule Biophysics seek parties to co-develop fluorescent nanodiamonds for use as in vivo and in vitro optical tracking probes toward commercialization.
NCI and NHLBI investigators invented a robust and easily implemented method of synthesizing silica-coated nanodiamonds for imaging and therapeutic applications. A patent estate covering these methods is offered for licensing to commercial entities. The method generally includes coating nanodiamonds with a silica precursor, e.g, tetraethylorthosilicate (TEOS), inside liposomes. The liposomes are then removed to yield a final product that is stable, monodisperse, and easy to functionalize.
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Development Stage:
Prototype
Inventors:
Martin Brechbiel (NCI) ➽ more inventions...
Keir Neuman (NHLBI) ➽ more inventions...
Intellectual Property:
US Application No. 61/672,996
US Provisional Application No. 61/711,702
Publications:
Yu SJ, et al. Bright fluorescent nanodiamonds: no photobleaching and low cytotoxicity. PMID 16351080
Wilson RM. Nanodiamonds are promising quantum probes of living cells. DOI 10.1063/PT.3.1204
Chow EK, et al. Nanodiamond therapeutic delivery agents mediate enhanced chemoresistant tumor treatment. PMID 21389265
Krueger A. New carbon materials: biological applications of functionalized nanodiamond materials. PMID 18033700
Collaboration Opportunity:
Licensing only
Licensing Contact:
John Hewes, Ph.D.
Email: John.Hewes@nih.gov
Phone: 240-276-5515
OTT Reference No: E-175-2012
Updated: Oct 6, 2020