Device for Selective Partitioning of Frozen Cellular Products

Cryopreservation using liquid nitrogen frozen polyvinyl bags allows for storing cellular materials for extended periods while maintaining their activity and viability. Such bags are commonly used in the clinic to store blood products including blood cells, plasma, hematopoietic stem cells, umbilical cord blood for future uses including transplantation. These materials, typically obtained in limited quantities, may be of great therapeutic value, as is the case of stem cells or cord blood derived cells which can be used to potentially treat a number of diseases. Currently, even if only a small portion of the cryopreserved sample is needed the whole bag must be thawed, wasting much of the sample or rendering the remaining sample susceptible to contamination since it cannot be effectively refrozen or sterilized. The present device meets an unmet need for retrieving a portion of a frozen sample stored in polyvinyl cryopreserved bags, resealing the remainder of the sample and preserving the cryopreserved state and integrity of the rest of the cellular product without compromising viability and sterility.

Potential Commercial Applications: Competitive Advantages:
  • Partitioning cryopreserved cell products
  • Maintenance of sterility of partitioned product
  • Maintenance of viability of partitioned product
  • Resealing of cryopreservation bag
  • Multiple use of patient derived cellular products
  • Cryopreservation
  • Cellular Products
  • Hematopoietic stem cells
  • Umbilical cord blood
  • iPSCs
  • Transplantation
  • Chronic spinal cord injury
  • Neurological disorders
  • Cancer immunotherapy
  • Cell banking
  • Cell replacement therapy

Development Stage:


Richard Childs (NHLBI)  ➽ more inventions...

Sumithira Vasu (CC)  ➽ more inventions...

Intellectual Property:
U.S. Pat: 8,790,597 issued 2014-07-29
U.S. Pat: 9,296,500 issued 2016-03-29
PCT Application No. PCT/US2010/033575
US Application No. 14/305,578
Related international patents/patent applications

Collaboration Opportunity:

The National Heart, Lung, and Blood Institute is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize Device for Partitioning Cryopreserved Cellular Products. For collaboration opportunities, please contact Cecilia Pazman, Ph.D. at 301.594.4273 or

Licensing Contact:
Denise Crooks,
Phone: 301-435-0103

OTT Reference No: E-173-2009-0
Updated: Jun 29, 2015