NAG-1: A Non-Steroidal Anti-Inflammatory Drug Related Gene Which Has Anti-Tumorigenic Properties


Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used in the treatment of inflammatory disease, and their anti-inflammatory effects are believed to result from their ability to inhibit the formation of prostaglandins by prostaglandin H synthase (COX). Two forms of prostaglandin H have been identified, COX-1 and COX-2. The former seems to be constitutively expressed in a variety of tissues while the high expression of the latter has been reported in colorectal tumors. NSAIDs have been shown to be effective in reducing human colorectal cancers and possibly breast and lung cancers. While the exact mechanism(s) by which NSAIDs function has not been elucidated, they could potentially play a critical role in detecting, diagnosing and treating inflammatory diseases as well as cancer. The present invention relates to screening methods for the identification of agonistic and/or antagonistic agents for the activation of the promoter region of NAG-1. Additional claims are directed to 1) the DNA sequence of NAG-1, 2) compositions containing the NAG-1 sequence and 3) methods for treating cancer patients using NAG-1.

Inventors:

Thomas Eling (NIEHS)  ➽ more inventions...

Baek Seung (NIEHS)  ➽ more inventions...

Richard Diaugustine (NIEHS)  ➽ more inventions...


Intellectual Property:
US Pat: 7,141,661 issued 2006-11-28
US Application No. 11/563,586 filed on 2006-11-27
US Application No. 10/363,514 filed on 2003-08-15
PCT Application No. PCT/US01/27544 filed on 2001-09-06
US Application No. 12/463,666 filed on 2009-05-11

Licensing Contact:
Vidita Choudhry, Ph.D.
Email: vidita.choudhry@nih.gov
Phone: 301-594-4095

OTT Reference No: E-170-2000-0
Updated: Dec 1, 2000