Monoclonal Antibody to the Protein NCOA6 (also called ASC-2, AIB-3)


The invention relates to monoclonal antibodies that bind to the transcription factor NCOA6 (ASC-2, AIB-3, TRB, TRAP250, NRC). The antibodies have proven successful reagents for Western blotting and for purifying complexes containing NCOA6. The Western blot experiments revealed that NCOA6 is over-expressed in several breast cancer cell lines, and the purification experiments identified a protein complex containing NCOA6 (the ASCOM complex). The monoclonal antibodies may be useful reagents for studying the role of NCOA6 in transcription and for studying the ASCOM complex.

Inventors:

Paul Meltzer (NHGRI)  ➽ more inventions...


Intellectual Property:

Publications:
Young-Hwa Goo et al., "Activating Signal Cointegrator 2 Belongs to a Novel Steady-State Complex That Contains a Subset of Trithorax Group Proteins," Mol. Cell. Biol. (Jan 2003) 23(1):140-149; DOI: 10.1128/MCB.23.1.140-149.2003.
Soo-Kyung Lee et al., "A Nuclear Factor, ASC-2, as a Cancer-amplified Transcriptional Coactivator Essential for Ligand-dependent Transactivation by Nuclear Receptors in Vivo," J. Biol. Chem. (26 Nov 1999) 274(48):34283-34893.

Licensing Contact:
Eggerton Campbell, Ph.D.
Email: eggerton.campbell@nih.gov
Phone: 301-402-1648

OTT Reference No: E-168-2005-0
Updated: Aug 1, 2005