T Cell-Based Adoptive Transfer Immunotherapy for Polyomavirus-Associated Pathologies
Available for licensing are methods to generate T cells responsive to multiple polyomaviruses. The resulting T cell populations could be useful in treating immunosuppressed individuals with polyomavirus infections or polyomavirus-associated pathologies such as Merkel cell carcinoma (MCC), polyomavirus-associated nephropathy (PVAN), hemorrhagic cystitis, progressive multifocal leukoencephalopathy (PML), and trichodysplasia spinulosa (TS). The methods could also be used to restore polyomavirus-specific immunity in immunocompromised individuals.
Potential Commercial Applications: | Competitive Advantages: |
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Development Stage:
- Early-stage
- In vitro data available
Related Invention(s):
E-168-2011-0
E-549-2013-0
Inventors:
Christopher Buck (NCI) ➽ more inventions...
John Barrett (NHLBI) ➽ more inventions...
Dhanalakshmi Chinnasamy (NHLBI) ➽ more inventions...
Pawel Muranski (NHLBI) ➽ more inventions...
Intellectual Property:
PCT Application No. PCT/US2015/059021
US Application No. 62/075,726
Collaboration Opportunity:
The National Heart, Lung, and Blood Institute is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize methods to generate T cells responsive to multiple polyomaviruses. For collaboration opportunities, please contact Dr. Vincent Kolesnitchenko at kolesniv@nhlbi.nih.gov.
Licensing Contact:
Michael Shmilovich, J.D.
Email: shmilovm@mail.nih.gov
Phone: 301-435-5019
OTT Reference No: E-166-2014-0
Updated: Sep 12, 2017