Intra-bone Drug Delivery Device and Method

The invention pertains to devices for directly infusing cellular therapeutics into patient bone. The device monitors intra-bone pressure using pressure sensors disposed at its proximal end and adjusts infusion pressures during infusion such that intra-bone pressure does not exceed levels of systemic blood pressure. Such devices, apparatus and methods are particularly suitable for use in performing bone marrow transplants, particularly transplants that utilize cord blood as a stem cell source.

Potential Commercial Applications: Competitive Advantages:
  • Drug delivery to bones
  • Therapeutic uptake efficiency
  • Drug delivery efficiency
  • Target specificity

Development Stage:
  • In vitro data available
  • Prototype

Related Invention(s):


Robert Hoyt (NHLBI)  ➽ more inventions...

Randall Clevenger (NHLBI)  ➽ more inventions...

Jeremy Pantin (NHLBI)  ➽ more inventions...

Timothy Hunt (NHLBI)  ➽ more inventions...

Omer Aras (CC)  ➽ more inventions...

Richard Childs (NHLBI)  ➽ more inventions...

Intellectual Property:
US Pat: - issued -
PCT Application No. PCT/US2014/019401 filed on 2014-02-28
US Application No. 61/771,463 filed on 2013-03-01

Pantin JM, et al. "Optimization of an Intra-Bone Hematopoietic Stem Cell Delivery Technique in a Swine Model." Poster abstract presented at the 54th ASH Annual Meeting and Exposition, Atlanta, Georgia, December 8-11, 2012. Poster Abstract
Pantin JM, et al. PMID 25656824

Collaboration Opportunity:

The National Heart, Lung, and Blood Institute is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize Intra-bone Drug Delivery Device and Method. For collaboration opportunities, please contact Denise Crooks at

Licensing Contact:
Denise Crooks,
Phone: 301-435-0103

OTT Reference No: E-165-2012-0
Updated: Feb 19, 2015