Real-Time PCR Assay for Specific Detection of Haemophilus influenzae Serotypes A and B

Haemophilus influenzae is responsible for life-threatening respiratory infections including meningitis. This assay allows for the qualitative detection of the bacterial meningitis pathogen H. influenzae serotype A (Hia) and serotype B (Hib) in fluid samples, without detecting any of the other serotypes of H. influenzae. This invention is capable of detecting even the very small numbers of Hia or Hib within clinical specimens.

Potential Commercial Applications: Competitive Advantages:
  • Meningitis nucleic acid-based diagnostics for testing clinical samples
  • Useful for public health monitoring programs
  • Surveillance of circulating H. influenzae serotypes
  • Easily adapted to a real-time PCR assay (monoplex or multiplex) kit
  • Rapid, accurate and specific, especially when compared to sero-diagnostic approaches
  • No further testing need, presently ready for commercialization

Development Stage:
  • Early-stage
  • Pre-clinical
  • In vitro data available


Jennifer Thomas (CDC)  ➽ more inventions...

Xin Wang (CDC)  ➽ more inventions...

Cynthia Hatcher (CDC)  ➽ more inventions...

Raydel Anderson (CDC)  ➽ more inventions...

Mary Theodore (CDC)  ➽ more inventions...

Leonard Mayer (CDC)  ➽ more inventions...

Intellectual Property:
U.S. Pat: 10,683,558 issued 2020-06-16
U.S. Pat: 10,669,591 issued 2020-06-02
U.S. Pat: 9,593,385 issued 2017-03-14
PCT Application No. PCT/US2012/022753
US Application No. 13/996,913

Licensing Contact:
Karen Surabian, J.D., M.B.A.
Phone: 301-594-9719

OTT Reference No: E-164-2013-0
Updated: Jan 16, 2014