A Simple Colorimetric Assay for Anti-malarial Drugs Quality Assurance and Rapid, On-site Counterfeit Detection
This CDC assay aims to lessen the anti-malarial drug counterfeiting epidemic by testing for the artemisinin-type drugs (the active compound), through the use of a simple, inexpensive colorimetric test. Poor quality and counterfeit drugs pose an immediate threat to public health and undermine malaria control efforts, resulting in resistant-parasites and invalidates effective compounds, i.e. the artemisinins.
In response to this threat, CDC researchers have developed a simple, inexpensive, field-adapted colorimetric test to determine artemesin-derivative authenticity in anti-malarial tablets. This assay exploits a chemical reaction in which the active element in question readily reacts under mild conditions with diazonium salts producing a visually distinct green-colored product. The resultant product delineates a positive correlation between color intensity and the drug's concentration of active-compound; counterfeit drugs will have no or little change in color.
Potential Commercial Applications: | Competitive Advantages: |
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Development Stage:
- In vitro data available
- In situ data available (on-site)
Inventors:
Michael Green (CDC) ➽ more inventions...
Intellectual Property:
U.S. Pat: 8,435,794 issued 2013-05-07
PCT Application No. PCT/US2008/082466
US Application No. 12/741,434
Publications:
Green MD, et al. PMID 11108540
Green MD, et al. PMID 11737833
Licensing Contact:
Jeremiah Mitzelfelt,
Email: jeremiah.mitzelfelt@nih.gov
Phone: 301-443-8518
OTT Reference No: E-161-2013-0
Updated: Jan 20, 2014