Cytochromes P450 CYP2J and CYP2C Polyclonal Antibodies and Recombinant Proteins


The National Institutes of Health announces polyclonal antibodies against mouse cytochrome P450s CYP2J and CYP2C. Cytochrome P450s catalyze the metabolism of a wide range of exogenous compounds, including drugs, industrial chemicals, environmental pollutants, and carcinogens. The 2C family of cytochrome P450 metabolizes an extensive number of drugs which include tolbutamide, S-Warfarin, mephenytoin, diazepam and taxol. Many of the P450 enzymes are also active in the NADPH-dependent oxidation of arachidonic acid to various eicosanoids found in several species. The 2J family is expressed at high levels in the heart and has been shown to metabolize both arachidonic acid and linoleic acid. The CYP2J and CYP2C subfamily members have a wide tissue distribution and may be useful as model systems for studies of cardiovascular disease, drug metabolism and toxicity.

Recombinant proteins of mouse cytochrome P450s CYP2C and CYP2J have also been expressed and can be used as controls in immunoblotting, as well as for metabolism studies.

Potential Commercial Applications: Competitive Advantages:
  • These antibodies can be used to study the expression of the P450s in various tissues by immunohistochemistry and immunoblotting.
  • The recombinant proteins can be used as controls in immunoblotting as well as for metabolism studies.
 
  • The CYP2J and CYP2C subfamily members have a wide tissue distribution and may be useful as model systems for studies of cardiovascular disease, drug metabolism and toxicity.


Development Stage:
In vitro data available

Inventors:

Darryl Zeldin (NIEHS)  ➽ more inventions...


Intellectual Property:
Research Material — Patent protection has not been pursued for this technology.

Collaboration Opportunity:

The NIEHS is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize antibodies against mouse cytochrome P450s CYP2J and CYP2C. For collaboration opportunities, please contact Sharon Soucek, Ph.D. at sharon.soucek@nih.gov.


Licensing Contact:
Vidita Choudhry, Ph.D.
Email: vidita.choudhry@nih.gov
Phone: 301-594-4095

OTT Reference No: E-153-2011-0
Updated: Sep 4, 2020