Regenerative Therapy for Cartilage Damage

The subject technology discloses a tissue engineering method for treating cartilage damage. Stem cells from bone marrow are attached to a novel scaffold, hyaluronic acid-coated fibrin microbeads, and transferred to a live host to form cartilage. The regenerated cartilage is stable and not hypertrophic, which has been problematic in the current regenerative methods.

Potential Commercial Applications: Competitive Advantages:
  • A novel scaffold, hyaluronic acid-coated fibrin microbeads.
  • Cartilage repair.
  • Coating with hyaluronic acid makes the fibrin microbeads more stable for mature cartilage formation.
  • The new hyaline cartilage is stable and hypertrophy-resistant.


Pamela Robey (NIDCR)  ➽ more inventions...

Mitchell Shirvan

Rafael Gorodetsky

Sergei Kuznetsov (NIDCR)  ➽ more inventions...

Astar Lazmi-Hailu

Intellectual Property:
US Application No. 62/513,874
PCT Application No. PCT/US2018/035448
US Application No. 16/616,418

Collaboration Opportunity:

The National Institute of Dental and Craniofacial Research is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize the novel methods for cartilage repair. For collaboration opportunities, please contact David Bradley, Ph.D. at

Licensing Contact:
Vladimir Knezevic, M.D.
Phone: 301.443.5560

OTT Reference No: E-152-2017-0
Updated: Jan 25, 2018