Human Rotavirus Strains and Vaccines for Neonatal Childhood Protection

This invention relates to rotavirus vaccine compositions and methods of vaccination. Rotaviral infection is the most commonly occurring gastrointestinal illness of children world, affecting both developed and developing economies. Additionally, rotavirus infections can affect livestock (especially calves and piglets), and resulting mortality/morbidity cause major economic losses for farmers and nations each year.

The vaccine strains include Rotavirus A CDC-9 (P[4]Gl) and CDC-66 (P[4]G2 serotype). These strains represent common rotavirus serotypes and may serve as improvements or alternatives to current live, oral rotavirus vaccine strains. Further, this technology has demonstrated efficacy in a large animal (piglets) modeling.

Potential Commercial Applications: Competitive Advantages:
  • Novel rotavirus vaccines
  • Neonatal/childhood vaccination initiatives
  • Rotavirus surveillance programs, important for both developing and developed nations
  • Isolated strains are representative of those involved in community-acquired infection
  • Suitable for the development of improved, broadly effective rotavirus vaccines
  • Can be developed for injection and/or oral vaccine administration
  • Derived vaccines may be administered alone or in combination with other vaccines

Development Stage:
  • In vitro data available
  • In vivo data available (animal)

Related Invention(s):


Baoming Jiang (CDC)  ➽ more inventions...

Roger Glass (CDC)  ➽ more inventions...

Yuhuan Wang (CDC)  ➽ more inventions...

Jon Gentsch (CDC)  ➽ more inventions...

Intellectual Property:
US Pat: 8,822,192 issued 2014-09-02
PCT Pat: 9,974,851 issued 2018-05-22
US Pat: 9,498,526 issued 2016-11-22
US Pat: 10,500,269 issued 2019-12-10
US Application No. 14/461,663 filed on 2014-08-18
US Application No. 15/956,662 filed on 2018-04-18
US Application No. 16/672,168 filed on 2019-11-01
Various international filings pending or deferred

Esona MD, et al. [PMID 20009519]
Wang Y, et al. [PMID 20558244]
Jiang B, et al. [PMID 23744507]

Licensing Contact:
Karen Surabian, J.D., M.B.A.
Phone: 301-594-9719

OTT Reference No: E-150-2013-0
Updated: Dec 26, 2019