Use of Vitronectin as a Biomarker for the Detection of Dengue Hemorrhagic Fever
Dengue hemorrhagic fever (DHF) is a severe, potentially deadly infection spread by mosquitos. CDC scientists have identified vitronectin as an important biomarker of DHF. They have shown vitronectin is significantly reduced in DHF and severe dengue infections when compared to dengue non-hemorrhagic fever patients. Presently, DHF is established by assessing antibody concentrations and other rule-of-thumb criteria, but often these assays can be difficult to interpret and lead to false conclusions. Establishing vitronectin levels provides a specific, novel biomarker for DHF, leading to increased accuracy in clinical diagnoses and improved patient outcomes.
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Development Stage:
- Pre-clinical
- In vitro data available
Inventors:
Elizabeth Hunsperger (CDC) ➽ more inventions...
Momar Ndao
Kay Tomashek (CDC) ➽ more inventions...
Betty Poole-Smith (CDC) ➽ more inventions...
Intellectual Property:
US Application No. 61/443,554
PCT Application No. PCT/US12/025472
US Application No. 13/985,507
Publications:
Poole-Smith BK, et al. Discovery and Validation of Prognostic Biomarkers for Severe Dengue by Proteomic Screening. International Conference on Emerging Infectious Diseases 2012: poster and oral presentation abstracts. Emerg Infect Dis. 2012 Mar. http://wwwnc.cdc.gov/eid/pdfs/ICEID2012.pdf https://wwwnc.cdc.gov/eid/pdfs/ICEID2012.pdf
Licensing Contact:
Jeremiah Mitzelfelt,
Email: jeremiah.mitzelfelt@nih.gov
Phone: 301-443-8518
OTT Reference No: E-147-2013-0
Updated: Aug 13, 2013