Use of Vitronectin as a Biomarker for the Detection of Dengue Hemorrhagic Fever


Dengue hemorrhagic fever (DHF) is a severe, potentially deadly infection spread by mosquitos. CDC scientists have identified vitronectin as an important biomarker of DHF. They have shown vitronectin is significantly reduced in DHF and severe dengue infections when compared to dengue non-hemorrhagic fever patients. Presently, DHF is established by assessing antibody concentrations and other rule-of-thumb criteria, but often these assays can be difficult to interpret and lead to false conclusions. Establishing vitronectin levels provides a specific, novel biomarker for DHF, leading to increased accuracy in clinical diagnoses and improved patient outcomes.

Potential Commercial Applications: Competitive Advantages:
  • Diagnostic biomarker of DHF
  • Point-of-care diagnostic testing
  • Enzyme-linked immunosorbent assay (ELISA) for clinical and laboratory use
 
  • While there are commercially-available ELISAs to detect vitronectin, these products have not been used for dengue diagnosis
  • Vitronectin assessment assays provide a novel, specific biomarker for the DHF disease state
  • Easily developed for serologic diagnostic assays


Development Stage:
  • Pre-clinical
  • In vitro data available


Inventors:

Elizabeth Hunsperger (CDC)  ➽ more inventions...

Momar Ndao

Kay Tomashek (CDC)  ➽ more inventions...

Betty Poole-Smith (CDC)  ➽ more inventions...


Intellectual Property:
US Application No. 61/443,554
PCT Application No. PCT/US12/025472
US Application No. 13/985,507

Publications:
Poole-Smith BK, et al. Discovery and Validation of Prognostic Biomarkers for Severe Dengue by Proteomic Screening. International Conference on Emerging Infectious Diseases 2012: poster and oral presentation abstracts. Emerg Infect Dis. 2012 Mar. http://wwwnc.cdc.gov/eid/pdfs/ICEID2012.pdf https://wwwnc.cdc.gov/eid/pdfs/ICEID2012.pdf

Licensing Contact:
Jeremiah Mitzelfelt,
Email: jeremiah.mitzelfelt@nih.gov
Phone: 301-443-8518

OTT Reference No: E-147-2013-0
Updated: Aug 13, 2013