Human T Cell Line Chronically Infected With HIV


A stable line of human T cells (ACH-2) was developed in which cells infected chronically with the AIDS virus (HIV) remained nonproductive prior to exposure to phorbol esters or human cytokines. This situation mimics the latent state of HIV and the development of AIDS in humans and indicates that the full-blown disease may be triggered by cellular-derived substances (e.g., cytokines). This is the first description of such a cell line.

Inventors:

Douglas Powell (NIAID)  ➽ more inventions...

Kathleen Clouse (NIAID)  ➽ more inventions...


Intellectual Property:
U.S. Pat: 5,459,056 issued 1995-10-17

Licensing Contact:
Su Cheng (Dana) Hsu, M.S., J.D.
Email: dh164a@nih.gov
Phone: 240-627-3698

OTT Reference No: E-143-1989-0
Updated: Jan 1, 2001