Adeno-Associated Virus Gene Therapy for Diabetes and Obesity
This invention is directed to adeno-associated virus (AAV) vector delivery of exendin-4 (Ex-4) to salivary glands as treatment for diabetes and obesity. Ex-4 is a potent and long-acting agonist of the receptor for glucagon-like peptide 1 (GLP-1). Scientists at NIDCR have shown that AAV-mediated delivery of Ex-4 resulted in improved glucose homeostasis and weight profile in two rat models of obesity and type 2 diabetes. Further, AAV-mediated delivery of Ex-4 to rat salivary glands resulted in localized and sustained expression of Ex-4 that was biologically active and well tolerated.
AAV-mediated delivery of Ex-4 is superior to administering GLP-1 analogs in that AAV-Ex-4 expression is more stable and longer acting. Like GLP-1 analogs, Ex-4 expression also potentially provides beneficial effects like reduced hypoglycemia, appetite suppression, and potential weight loss.
Potential Commercial Applications: | Competitive Advantages: |
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Development Stage:
- Early-stage
- In vitro data available
- In vivo data available (animal)
Inventors:
John Chiorini (NIDCR) ➽ more inventions...
Giovanni Di Pasquale (NIDCR) ➽ more inventions...
Edward Mannucci
Intellectual Property:
U.S. Pat: 10,300,095 issued 2019-05-28
U.S. Pat: 9,511,103 issued 2016-12-06
PCT Application No. PCT/US12/34268
US Application No. 14/112,790
US Application No. 16/396,262
Publications:
Di Pasquale G, et al. PMID 22808093
Collaboration Opportunity:
The NIDCR is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize treatment of diabetes by expression NGF-extendin 4 protein. For collaboration opportunities, please contact David Bradley, Ph.D. at 301-402-9242 or bradleyda@nidcr.nih.gov.
Licensing Contact:
Vladimir Knezevic, M.D.
Email: vlado.knezevic@nih.gov
Phone: 301.443.5560
OTT Reference No: E-142-2011-0
Updated: Nov 2, 2016