Recombinant Proteins Of A Pakistani Strain Of Hepatitis E And Their Use In Diagnostic Methods And Vaccines
A strain of hepatitis E virus from Pakistan (SAR-55) implicated in an epidemic of enterically transmitted non-A, non-B hepatitis, now called hepatitis E, is disclosed. The invention relates to the expression of the whole structural region of SAR-55, designated open reading frame 2 (ORF-2), in a eukaryotic expression system. The expressed protein is capable of forming HEV virus-like particles which can serve as an antigen in diagnostic immunoassays and as an immunogen or vaccine to protect against infection by hepatitis E.
Inventors:
Sergei Tsarev (NIAID) ➽ more inventions...
Suzanne Emerson (NIAID) ➽ more inventions...
Robert Purcell (NIAID) ➽ more inventions...
Intellectual Property:
U.S. Pat: 6,207,416 issued 2001-03-27
U.S. Pat: 6,787,145 issued 2004-09-07
Licensing Contact:
Peter Soukas, J.D.
Email: peter.soukas@nih.gov
Phone: 301-496-2644
OTT Reference No: E-141-1992-2
Updated: Jul 6, 2020