Optimized Variants of the Broadly Neutralizing HIV-1 gp41 Antibody, 10E8


Scientists at the National Institute of Allergy and Infectious Diseases (NIAID) recently discovered a human neutralizing antibody, 10E8, that binds to the GP41 protein of HIV-1 and prevents infection by HIV-1. 10E8 potently neutralizes up to 98% of genetically diverse HIV-1 strains.

By engineering the 10E8 antibody, NIAID scientists have improved the properties of 10E8 that affect manufacturability, such as solubility, while preserving its neutralizing breadth and potency.

10E8 variants are useful for passive protection from infection, as therapeutics, and as a tool for vaccine development.

This technology is available for licensing for commercial development in accordance with 35 U.S.C. 209 and 37 CFR Part 404.

Potential Commercial Applications: Competitive Advantages:
  • Passive protection to prevent HIV infection
  • Passive protection to prevent mother-to-infant HIV transmission
  • Gene-based vectors for anti-gp41 antibody expression
  • Therapeutics for elimination of HIV infected cells that are actively producing virus
 
  • Among the most potent and broadly neutralizing human antibodies isolated to date
  • Broad reactivity and high affinity to most HIV-1 strains
  • Improved manufacturability relative to the natural 10E8 antibody


Related Invention(s):
E-253-2011-0


Inventors:

John Mascola (NIAID)  ➽ more inventions...

Mark Connors (NIAID)  ➽ more inventions...

Ivelin Georgiev (NIAID)  ➽ more inventions...

Young Do Kwon (NIAID)  ➽ more inventions...

Peter Kwong (NIAID)  ➽ more inventions...

Gilad Ofek (NIAID)  ➽ more inventions...

Baoshan Zhang (NIAID)  ➽ more inventions...

Krisha McKee (NIAID)  ➽ more inventions...

Gwo-Yu Chuang (NIAID)  ➽ more inventions...

Sijy O'Dell (NIAID)  ➽ more inventions...

Robert Bailer (NIAID)  ➽ more inventions...

Mark Louder (NIAID)  ➽ more inventions...

Mangaiarkarasi Asokan (NIAID)  ➽ more inventions...

Jonathan Cooper (NIAID)  ➽ more inventions...

Kevin Carlton (NIAID)  ➽ more inventions...

Michael Bender (NIAID)  ➽ more inventions...

Amarenda Pegu (NIAID)  ➽ more inventions...

Lisa Kueltzo (NIAID)  ➽ more inventions...

Lawrence Shapiro

Tatyana Gindin

Richard Schwartz (NIAID)  ➽ more inventions...


Intellectual Property:
US Application No. 62/250,360
PCT Application No. PCT/US2016/060390
US Application No. 15/772,443
CA Application No. 3003878
CN Application No. 201680077520.X
EP Application No. 16801639.2
IN Application No. 201837016184
ZA Application No. 2018/02875
AU Application No. 2016349392

Publications:
Kwon YD, et al. PMID 27053554

Licensing Contact:
Vince Contreras, Ph.D.
Email: vincent.contreras@nih.gov
Phone: 240-669-2823

OTT Reference No: E-133-2015-0
Updated: Nov 19, 2018