Novel Vaccine for Prevention and Treatment of Chlamydia Infection

The invention provides novel vectors, attenuated pathogens, compositions, methods and kits for preventing and/or treating chlamydia infections.

Chlamydia trachomatis is an obligate intracellular human pathogen with a unique biphasic developmental growth cycle. It's the etiological agent of trachoma, the world's leading cause of preventable blindness and the most common cause of bacterial sexually transmitted disease. C. trachomatis isolates maintain a highly conserved plasmid and naturally occurring plasmidless clinical isolates are rare, implicating its importance in chlamydial pathogenesis. Understanding the plasmid's role in chlamydial pathogenesis at a molecular level is an important objective for the future control of chlamydial infections. The NIAID inventor had studied chlamydia strains in both non-human primate and murine infectious models providing evidence that plasmids play an important role in chlamydial pathogenesis. In addition, the study results of macaque model of trachoma supports the use of plasmid-deficient organisms as novel live-attenuated chlamydial vaccines.

Potential Commercial Applications: Competitive Advantages:
  • Novel live-attenuated chlamydial vaccines.
  • Virulence attenuated vectors that can be used as vaccines against chlamydia.
  • Combination of vector with attenuated pathogenic agent improves the stability and replicative capacity of the pathogen.
  • Features nucleic acids, attenuated pathogens, compositions, methods and kits to treat and prevent chlamydia infections.

Development Stage:
    In vitro data available In vivo data available (animal) In vivo data available (human)
  • Prototype


Harlan Caldwell (NIAID)  ➽ more inventions...

Intellectual Property:
U.S. Pat: 10,258,682 issued 2019-04-16
PCT Application No. PCT/US2014/011799
US Application No. 14/761,520

Song L, et al. PMID 23319558
Kari L, et al. PMID 21987657

Collaboration Opportunity:

The National Institute of Allergy and Infectious Diseases, Laboratory of Clinical Infectious Diseases, is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize chlamydia vaccine. For collaboration opportunities, please contact Harlan D. Caldwell, Ph.D. at

Licensing Contact:
Charles Rainwater,
Phone: 301-496-2644

OTT Reference No: E-133-2012-0
Updated: Aug 11, 2015