Rapid Detection of Antiretroviral(s) Drug-Resistant HIV-1 within Clinical Samples

One of the problems with the development of current therapies for HIV infection is that the virus rapidly develops resistance to drugs such as reverse transcriptase (RT) inhibitors. CDC researchers have developed an enzyme-based methodology for detecting phenotypic resistance to antiretroviral drugs whose mode of action decreases the efficiency of the HIV-1 RT enzyme.

This invention will enhance clinical monitoring by providing data that tells physicians if and when the HIV-1 infecting a patient has become resistant to commonly used antiretroviral drugs, such as zidovudine/azidothymidine (AZT), nevirapine and lamivudine (3TC). This invention provides physicians and patient care facilities with a simple, rapid lab test that will tell them when a particular antiviral drug is not or no longer beneficial for a patient. Additionally this technology is superior to current culture-based methods for determining phenotypic resistance to HIV antiviral drugs, which are time-consuming and labor-intensive and therefore impractical for clinical monitoring.

Potential Commercial Applications: Competitive Advantages:
  • Clinical monitoring of individual patient antiretroviral therapy
  • HIV/AIDS public health programs
  • Surveillance of retroviral drug resistance
  • Rapid diagnostic which greatly reduces time and labor for improved clinical monitoring of HIV treatment
  • Ready for commercialization
  • Easily adapted to kit format
  • Assists continued usefulness of common antiretroviral therapeutics

Development Stage:
In vitro data available

Related Invention(s):


Walid Heneine (CDC)  ➽ more inventions...

Thomas Folks (CDC)  ➽ more inventions...

Shinji Yamamoto (CDC)  ➽ more inventions...

Gerardo Lerma (CDC)  ➽ more inventions...

William Switzer (CDC)  ➽ more inventions...

Intellectual Property:
US Pat: 6,787,126 issued 2004-09-07
PCT Pat: 7,691,572 issued 2010-04-06
US Application No. 09/719,906 filed on 2001-07-30
US Application No. 60/090,051 filed on 1998-06-19
US Application No. 11/054,023 filed on 2005-02-09
Various international patents issued

Qari SH, et al. PMID 12212925

Licensing Contact:
Jeremiah Mitzelfelt,
Email: jeremiah.mitzelfelt@nih.gov
Phone: 301-443-8518

OTT Reference No: E-129-2013-0
Updated: Jan 20, 2014