Transgenic Mouse Model for Lupus and Other Autoimmune Diseases


The inventors have developed a series of transgenic mice that overexpress Toll-Like Receptor 7 (TLR7) at different levels. Overexpression of TLR7 in these mice results in a lupus-like syndrome, the intensity of which correlates with the level of overexpression. As the pathology in these mice results from the overexpression of a single gene, it represents a superior model for lupus and other autoimmune diseases compared to other existing mouse models that dysregulate multiple genes to achieve the same pathologic syndrome.

Two strains are currently available. The TLR7.Tg1 strain overexpresses TLR7 at approximately 16 times the wild-type level. The TLR7.Tg6 strain overexpresses TLR7 at approximately 4 times the level of a wild-type mouse; additionally, the transgene for this strain is located on the Y chromosome, which would be advantageous for cross-breeding to other mouse lines.

Inventors:

Jonathan Deane (NIAID)  ➽ more inventions...


Intellectual Property:
Research Tool -- patent protection is not being pursued for this technology

Publications:
P Pisitkun et al. Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication. Science 2006 Jun 16;312(5780):1669-1672. PubMed: 16709748

Licensing Contact:
Christopher Kornak, J.D.
Email: chris.kornak@nih.gov
Phone: 240-627-3705

OTT Reference No: E-128-2007-0
Updated: Aug 3, 2010